Preimplantation Genetic Testing (PGT):
What You Need to Know
What is Preimplantation Genetic Testing?
Preimplantation Genetic Testing (PGT) is a specialized procedure performed during IVF that examines embryos for genetic abnormalities before they’re transferred to the uterus. This testing analyzes cells from the trophectoderm (future placenta), without affecting the cells that will develop into the baby.
Watch this video to learn about preimplantation genetic testing (PGT) and how it helps with IVF success:
Types of Preimplantation Genetic Testing
PGT-A
- Formerly called: Preimplantation Genetic Screening (PGS)
- Tests for: Abnormal chromosome numbers (aneuploidy)
- Benefits: Reduces miscarriage risk and improves implantation rates
- Key fact: Aneuploidy is a major cause of failed implantation and miscarriage
PGT-M
- Formerly called: Preimplantation Genetic Diagnosis (PGD)
- Tests for: Specific inherited genetic diseases caused by single gene mutations
- Examples: Cystic fibrosis, Huntington's disease, sickle cell anemia, Tay-Sachs
- Also screens for: Sex-linked conditions (like hemophilia and muscular dystrophies)
PGT-SR
- Tests for: Structural chromosome abnormalities
- Recommended for: Patients with known chromosomal rearrangements
- Benefits: Helps prevent recurrent miscarriages caused by chromosomal issues
Advanced Testing Technology
Our clinic uses next-generation sequencing technology to detect mosaicism (when not all embryo cells are genetically identical).
This advanced approach:
- Determines the percentage of affected cells
- Provides more accurate genetic information
- Helps make informed decisions about embryo transfer
Who Should Consider PGT?
PGT may be recommended if you:
- Carry known genetic disorders
- Have experienced recurrent pregnancy loss
- Are of advanced maternal age (35+)
- Have had failed IVF cycles
- Want to reduce the risk of chromosomal abnormalities
Understanding the Costs and Risks
Costs
- PGT typically adds $4,000-$7,000 to IVF costs
- Includes specialized sampling and laboratory testing fees
Potential Risks
- Some genetic conditions may not be detected
- All embryos might be affected, leaving none for transfer
- Confirmation through prenatal testing is recommended during pregnancy
Genetic Counseling Support
Our clinic provides comprehensive genetic counseling to help you:
- Understand your specific genetic risks
- Navigate testing decisions
- Interpret results accurately
- Plan your family-building journey with confidence
Schedule a Consultation
Located in Raleigh, NC, Atlantic Reproductive is a premier fertility clinic serving patients throughout the Triangle area, including Durham, Cary, Chapel Hill, and Fayetteville.
Please contact us today to discuss how PGT can help you achieve your dream of a healthy family.